Chemical reactivities and relationship to electronic properties.Physical data and spectroscopic characteristics.Other nitrogenous natural products - alkaloids and nucleotidesįor each of these the following area will be considered.There are many organic functional group which contain nitrogen, the scope Nitrogenous Natural Products and Alkaloid Biosynthesis 6.1 Introduction 6.1.1 Amino-acids, Peptides, Proteins and Derived SubstancesĦ.1.3 Porphyrins, Chlorins and CobalaminsĦ.1.4 Purines, Pyrimidines, Nucleosides, Nucleotides 6.2 Alkaloid Biosynthesis a Amino Acids, Peptides andĥ.3 Amino Acid Synthesis 5.3.1 The Gabriel Synthesisĥ.3.3 Enantioselective Synthesis 5.4 Peptide and Protein Structureĥ.5.3 Peptide Synthesis in Nature 5.6 Summary 6. Amines 4.1 NomenclatureĤ.6 Synthesis 4.6.1 Alkylation Reactions 3.6.1.1 Generalģ.6.1.2 Alkylation of Phthalimide Anion-The Gabriel Synthesisģ.6.1.3 Alkylation of Bis(Phenylthio)Amine Anionģ.6.1.4 Alkylation of Trifluoromethanesulfonylamine 4.6.2 Reductive Methods 3.6.2.1 Reduction of Amidesģ.6.2.2 Reduction of Nitro Compounds or Azidesģ.6.2.3 Reduction of CN Multiple Bonded Systemsģ.6.2.4 Eschweiler-Clarke Synthesis 4.6.3 Hydrolytic Methods 3.6.3.1 Hydrolysis of Amidesģ.6.3.3 Meerwein's Salt 4.6.4 Rearrangements 3.6.4.1 General Reaction Schemeģ.6.4.7 Abnormal Beckmann Rearrangement 4.7 Reactions 4.7.1 Basicity and NucleophilicityĤ.7.4.2 Aromatics 4.7.5 Nitrosation 4.7.5.1 GeneralĤ.7.5.4 Tertiary Amines 4.7.6 Reaction with CarbonylsĤ.7.7 Oxidation 4.7.7.1 Oxygen Addition ReactionsĤ.7.7.2 Dehydrogenation of Amines 4.7.8 Deprotonation 4.8 Summary 5. Nitroso Compounds 3.1 Structureģ.4.3 Tertiary Aliphatics 3.5 Reactions 3.5.1 Addition and Condensationģ.5.4 Radical Addition-Spin Trapping 3.6 Summary 4. Nitro Alkanes and Nitro Arenes 2.1 StructureĢ.4 Synthesis of Nitro Compounds 2.4.1 Gas Phase Nitration of AlkanesĢ.4.3 Nitrate SN2 Displacement of Alkyl HalidesĢ.4.5 Aromatic Nitro Compounds 2.5 Reactions 2.5.1 a AnionsĢ.5.2.3 Ambident Nucleophiles 2.5.3 Reduction 2.5.3.1 GeneralĢ.5.3.6 Metal Hydrides 2.6 Summary 3. Introduction 1.1 Scopeġ.3 Course Objectives 2.
Vollhardt and Schore, 2nd Edition Chapters 21 and 26 with some fromĬhapter 22 Course Content 1. Were written by Matthew Parkinson and edited to match the CREDIT format This is a first year course given by Dr David Widdowson.
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